Publikationsverzeichnis Prof. Dr. Peter Licht

Wissenschaftliche Preise

"International Session Award" der japanischen Gesellschaft für Gynäkologie und Geburtshilfe 2000

Dissertation (Doktorarbeit)

Habilitation (Lehrbefugnis)

Embryo-maternaler Dialog und Implantation:  Untersuchungen zu molekularen Mechanismen der Regulation durch das Choriogonadotropin des Menschen (hCG).

Friedrich-Alexander-Universität Erlangen, Juni 2001

Originalpublikationen

Merz WE, Erlewein C, Licht P, Harbarth P  (1991)  The secretion of human chorionic gonadotropin as well as the alpha- and beta-messenger ribonucleic acid levels are stimulated by exogenous gonadoliberin pulses applied to first trimester placenta in a superfusion tissue culture system.   J Clin Endocrinol Metab 73: 84-92 
  
Licht P, Harbarth P, Merz WE  (1992)  Evidence for a modulation of human chorionic gonadotropin (hCG) subunit messenger ribonucleic acid levels and hCG secretion by gamma-aminobutyric acid (GABA) in human first trimester placenta in vitro.  Endocrinology 130: 490-496  
  
Licht P, Harbarth P, Merz WE  (1992)  GABA-mediated stimulation of hCG secretion suggests a parallelism in the control of central nervous and placental gonadotropin release.  Trophoblast Research 6: 151-161 
  
Lei ZM, Rao ChV, Környei JL, Licht P, Hiatt ES  (1993)  Novel expression of human chorionic gonadotropin / luteinizing hormone receptor gene in brain.  Endocrinology 132: 2262-2270 
  
Licht P, Lei ZM, Rao ChV, Merz WE  (1993)  Novel self-regulation of human chorionic gonadotropin in term pregnancy human placenta.  Endocrinology 133: 3014-3025 
  
Licht P, Cao H, Zuo J, Lei ZM, Rao ChV, Merz WE, Day, TG  (1994)  Lack of self-regulation of human chorionic gonadotropin biosynthesis in human choriocarcinoma cells.  J Clin Endocrinol Metab 78: 1188-1194 
  
Neuwinger J, Licht P, Munzer B, Sir-Petermann T, Siebzehnrübl E, Wildt L  (1996)  Substitution with testosterone as aromatizable substrate for induction of follicular maturation, estradiol production and ovulation in a patient with 17-hydroxylase deficiency.  Exp Clin Endocrinol Diabetes 104: 400-408 
  
Licht P, Lösch A, Dittrich R, Neuwinger J, Siebzehnrübl E, Wildt L  (1998)  Novel insights into human endometrial paracrinology and feto-maternal communication by intrauterine microdialysis.  Hum Reprod Update 4: 532-538 
  
Wildt L, Kissler S, Licht P, Becker W  (1998)  Transport in the human female genital tract and its modulation by oxytocin as assessed by Hysterosalpingoscintigraphy, Hysterotonography, Electrohysterography and Doppler sonography.  Hum Reprod Update 4: 655-666 
  
Licht P, Wildt L  (1998)  Gonadal and extragonadal receptors for human chorionic gonadotropin (hCG) and luteinizing hormone (LH).  Ass Reprod Rev 8: 152-172 
  
Licht P, Wildt L  (1998)  Luteale und extraluteale Rezeptoren für hCG und LH.  Zentralbl Gynacol 120: 98-105 
  
Renner C, Razeghi S, Uberall MA, Licht P, Wildt L, Dorr HG, Hensen J, Schweitzer S  (1999)  Hormone replacement therapy in galactosaemic twins with ovarian failure and severe osteoporosis.  J Inherit Metab Dis 22: 194-195  Beck EP, Vincenti D, Licht P, Berkholz A, Jager W, Lang N, Merkle E  (2000)  In vitro activity fo human chorionic gonadotropin (hCG)-doxorubicin conjugates against ovarian cancer cells.  Anticancer Res 20: 3001-3006 
  
Licht P, Russu V, Wildt L  (2001)  On the role of human chorionic gonadotropin (hCG) in the embryo-endometrial microenvironment – implications for differentiation and implantation.  Seminars Reprod Med  19: 37-47 
  
Licht P, Neuwinger J, Fischer O, Siebzehnrübl E, Wildt L  (2001)  Peripheral levels of vascular endothelial growth factor (VEGF) are higher in gonadotropin stimulated as compared to natural ovarian cycles.  Exp Clin Endocrinol Diabetes 109: 345 - 349 
  
Licht P, Russu V, Lehmeyer S, Wildt L  (2001)  Molecular aspects of direct LH/hCG effects on human endometrium – lessons from intrauterine microdialysis in the human female in vivo.  Reprod Biol 1: 10-19 
  
Licht P, Neuwinger J, Fischer O, Siebzehnrübl E, Wildt L  (2002)  VEGF plasma pattern in ovulation induction: evidence for an episodic secretion and lack of immediate effect of hCG.  Exp Clin Endocrinol Diabetes 110: 130-133 
  
Licht P, Russu V, Lehmeyer S, Möll J, Siebzehnrübl E, Wildt L  (2002)  Intrauterine microdialysis reveals a cycle-dependent regulation of endometrial insulin-like growth factor binding protein (IGFBP)-1 secretion by human chorionic gonadotropin in the human female in vivo.  Fertil Steril 78: 252-258 
  
Gebauer G, Fehm T, Beck EP, Berkholz A, Licht P, Jager W  (2003)  Cytotoxic effect of conjugates of doxorubicin and human chorionic goandotropin (hCG) in breast cancer cells.  Brest Cancer Res Treat 77: 125-31 
  
Licht P, v. Wolff M, Berkholz A, Wildt L  (2003)  Evidence for a cycle-dependent expression of full-length hCG/LH-receptor ribonucleic acid (mRNA) in human endometrium and decidua.  Fertil Steril 79 (Suppl. 1): 718-23 
  
Licht P, Russu V, Lehmeyer S, Wissentheit T, Siebzehnrübl E, Wildt L  (2003) Cycle-dependency of intrauterine vascular endothelial growth factor levels are correlated to decidualisation and corpus luteum function. Fertil Steril 80: 1228-33 
  
Moeller K-T, Schmidt A, Licht P, Hein A, Veitenhansel S, Wildt L (2003) Expiratorische CO2-Messung in der Zyklusüberwachung – ein einfacher und zuverlässiger Marker zur Bestimmung der fertilen Tage. J Fertil Reprod 13: 7-12 
  
Licht P, Herberth J, Wallwiener D, Wildt L  (2003)  Evidence for a modulation of apoptosis by recombinant human choriogonadotropin (r-hCG) in uterine leiomyoma cell cultures. Geburtsh Frauenheilk 63: 1262-6 
  
Gebauer G, Renner N, Fehm T, Berkholz A, Beck EP, Jaeger W, Licht P  (2004)  Expression and regulation of LH/hCG receptors in ovarian cancer and its correlation to doxorubicin sensitivity.  Am J Obstet Gynecol 190: 1621-8 
  
Filicori M,  Rao CV, Huhtaniemi I, Licht P, Tesarik J, Zygmunt M  (2005)  Novel concepts of human chorionic gonadotropin: reproductive system interactions and potential in the management of infertility.  Fertil Steril 84: 275-84 
  
Fluhr H, Krenzer S, Deperschmidt M, Zwirner M, Wallwiener D, Licht P(2006)  Human chorionic gonadotropin (hCG) inhibits IGFBP-1 and prolactin in decidualized human endometrial stromal cells.  Fertil Steril 86: 236-8 
  
Ott HW, Mattle V, Zimmermann U, Licht P, Moeller K, Wildt L  (2006) Symptoms of the Premenstrual Syndrome may be caused  by hyperventilation ?  Fertil Steril 86: 1001-e17-19 
  
Ott HW, Mattle V, Hadziomerovic D, Licht P, Doinghaus K, Rubbert A, Manger K, Manger B, Kalden J, Wildt L  (2007)  Treatment of hereditary angioneurotic oedema (HANE) with tibolone.  Clin Endocrinol (Oxf) 66: 180-4 
  
Sanches-Albisua I, Borell-Kost S, Mau-Holzmann UA, Licht P, Krägeloh-Mann I  (2007)  Increased frequency of severe major anomalies in children conceived by intracytoplasmatic sperm injection. Develop Med Child Neurol 49: 129-34 
  
Licht P, Fluhr H, Neuwinger J, Wallwiener D, Wildt L  (2007)  Is human chorionic gonadotropin (hCG) directly involved in the regulation of human implantation. Mol Cell Endocrinol 269: 85-92 

Fluhr H, Krenzer S, Stein G, Wesselborg S, Depperschmidt M, Wallwiener D, Zygmunt M, Licht P  (2007)  Interferon-gamma and tumor-necrosis-factor-alpha sensitize primarily resistant human endometrial stromal cells to FAS-mediated apoptosis. J Cell Sci 120: 4126-33

Fluhr H, Carli S, Depperschmidt M, Wallwiener D, Zygmunt M, Licht P (2008)  Differential effects of human chorionic gonadotropin and decidualisation on insulin-like growth factors-I and -II in human endometrial cells.  Fertil Steril 90(4 Suppl): 1384-9.

Hadzimerovic D, Moeller KD, Licht P, Hein A, Veithansel S, Kusmitsch M, Wildt L (2008) The biphasic pattern of end-expiratory carbon dioxide pressure: a method for identification of the fertile phase of the menstrual cycle.  Fertil Steril 90(3):731-6

Fluhr H, Krenzer S, Depperschmidt M, Wallwiener D, Zygmunt M, Bishop P, Licht P  (2008)  Human chorionic gonadotropin stimulates matrix-metalloproteinase-2 and -9 in cytotrophoblastic dells and decreases tissue inhibitor of metalloproteinases -1, -2, and -3 in decidualized endometrial stromal cells.  Fertil Steril 90(4 Suppl): 1390-5

Fluhr H, Ramp K, Krenzer S, Licht P, Zygmunt M  (2009)  Inverse regulation of the interferon-gamma receptor and its signaling in human endometrial stromal cells during decidualisation.   Fertil Steril 91(5 Suppl): 2131-6. 

Fluhr H, Sauter G, Steinmüller F, Licht P, Zygmunt M. (2009)  Nonapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on interleukin-6, leukemia inhibitory factor, interleukin-8, and monocyte chemoattractant protein 1 vary between undifferentiated and decidualized human endometrial stromal cells.  Fertil Steril 92: 1420-3

Fortbildungs- und Opinionartikel

Buchbeiträge

Licht P, Lei ZM, Rao ChV, Merz WE  (1993)  The presence and functional relevance of hCG/LH receptors in normal human placentae and choriocarcinomas.  In: Barnea ER, Check JH, Grudzinskas JG, Maruo T (Edts.): Implantation and Early Pregnancy in Humans, S. 235-246, Parthenon Publishers. 
  
Wildt L, Licht P, Neuwinger J  (1995)  Die Hyperandrogenämische Ovarialinsuffizienz: Neue therapeutische Ansatzpunkte aus endokrinologischer Sicht. In: Hensen J (Hrsg.): Fortschritte in Diagnostik und Therapie endokrinologischer Erkrankungen 1995, S. 175-193, W. Tümmels Verlag, ISBN 3-921590-30-2 
  
Wildt L, Licht P, Roth B, Rabenbauer B  (1997)  Hirsutismus und Hypertrichose - Pathogenese, Diagnostik und Therapie. In: Peter HH, Pfreundschuh M, Philipp T, Schölmerich J, Schuster HP, Sybrecht GW (Hrsg.): Klinik der Gegenwart 1997, S. III, 4:1-32 
  
Taubert HD, Licht P  (2004)  Normale Geschlechtsentwicklung und Entwicklungsstörungen. Gynäkologie und Geburtshilfe, 10. Auflage, Hrsg. Schmidt-Matthiesen,. Wallwiener, Schattauer Verlag 
  
Taubert HD, Licht P  (2004)  Familienplanung. Gynäkologie und Geburtshilfe, 10. Auflage, Hrsg. Schmidt-Matthiesen,. Wallwiener, Schattauer Verlag 
  
Taubert HD, Licht P  (2004)  Sterilität und Infertilität Gynäkologie und Geburtshilfe, 10. Auflage, Hrsg. Schmidt-Matthiesen, Wallwiener, Schattauer Verlag. 
  
Licht P  (2012)  Diagnostik der Sterilität, Infertilität. Therapiehandbuch Gynäkologie und Geburtshilfe – evidence based. Hrsg. Wacker, Sillem, Springer Verlag, Heidelberg. 

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