Publikationsverzeichnis Prof. Dr. Peter Licht
Wissenschaftliche Preise
"International Session Award" der japanischen Gesellschaft für Gynäkologie und Geburtshilfe 2000
Dissertation (Doktorarbeit)
Untersuchungen zu Regulationsprinzipien der Biosynthese des Choriogonadotropins des Menschen (hCG): Analogien zur neuroendokrinen Kontrolle der Gonadotropine und placentaspezifische Mechanismen.
Rupprecht-Karls-Universität Heidelberg, Biochemisches Institut II, Oktober 1995
Note : summa cum laude
Habilitation (Lehrbefugnis)
Embryo-maternaler Dialog und Implantation: Untersuchungen zu molekularen Mechanismen der Regulation durch das Choriogonadotropin des Menschen (hCG).
Friedrich-Alexander-Universität Erlangen, Juni 2001
Originalpublikationen
Merz WE, Erlewein C, Licht P, Harbarth P (1991) The secretion of human chorionic gonadotropin as well as the alpha- and beta-messenger ribonucleic acid levels are stimulated by exogenous gonadoliberin pulses applied to first trimester placenta in a superfusion tissue culture system. J Clin Endocrinol Metab 73: 84-92
Licht P, Harbarth P, Merz WE (1992) Evidence for a modulation of human chorionic gonadotropin (hCG) subunit messenger ribonucleic acid levels and hCG secretion by gamma-aminobutyric acid (GABA) in human first trimester placenta in vitro. Endocrinology 130: 490-496
Licht P, Harbarth P, Merz WE (1992) GABA-mediated stimulation of hCG secretion suggests a parallelism in the control of central nervous and placental gonadotropin release. Trophoblast Research 6: 151-161
Lei ZM, Rao ChV, Környei JL, Licht P, Hiatt ES (1993) Novel expression of human chorionic gonadotropin / luteinizing hormone receptor gene in brain. Endocrinology 132: 2262-2270
Licht P, Lei ZM, Rao ChV, Merz WE (1993) Novel self-regulation of human chorionic gonadotropin in term pregnancy human placenta. Endocrinology 133: 3014-3025
Licht P, Cao H, Zuo J, Lei ZM, Rao ChV, Merz WE, Day, TG (1994) Lack of self-regulation of human chorionic gonadotropin biosynthesis in human choriocarcinoma cells. J Clin Endocrinol Metab 78: 1188-1194
Neuwinger J, Licht P, Munzer B, Sir-Petermann T, Siebzehnrübl E, Wildt L (1996) Substitution with testosterone as aromatizable substrate for induction of follicular maturation, estradiol production and ovulation in a patient with 17-hydroxylase deficiency. Exp Clin Endocrinol Diabetes 104: 400-408
Licht P, Lösch A, Dittrich R, Neuwinger J, Siebzehnrübl E, Wildt L (1998) Novel insights into human endometrial paracrinology and feto-maternal communication by intrauterine microdialysis. Hum Reprod Update 4: 532-538
Wildt L, Kissler S, Licht P, Becker W (1998) Transport in the human female genital tract and its modulation by oxytocin as assessed by Hysterosalpingoscintigraphy, Hysterotonography, Electrohysterography and Doppler sonography. Hum Reprod Update 4: 655-666
Licht P, Wildt L (1998) Gonadal and extragonadal receptors for human chorionic gonadotropin (hCG) and luteinizing hormone (LH). Ass Reprod Rev 8: 152-172
Licht P, Wildt L (1998) Luteale und extraluteale Rezeptoren für hCG und LH. Zentralbl Gynacol 120: 98-105
Renner C, Razeghi S, Uberall MA, Licht P, Wildt L, Dorr HG, Hensen J, Schweitzer S (1999) Hormone replacement therapy in galactosaemic twins with ovarian failure and severe osteoporosis. J Inherit Metab Dis 22: 194-195 Beck EP, Vincenti D, Licht P, Berkholz A, Jager W, Lang N, Merkle E (2000) In vitro activity fo human chorionic gonadotropin (hCG)-doxorubicin conjugates against ovarian cancer cells. Anticancer Res 20: 3001-3006
Licht P, Russu V, Wildt L (2001) On the role of human chorionic gonadotropin (hCG) in the embryo-endometrial microenvironment – implications for differentiation and implantation. Seminars Reprod Med 19: 37-47
Licht P, Neuwinger J, Fischer O, Siebzehnrübl E, Wildt L (2001) Peripheral levels of vascular endothelial growth factor (VEGF) are higher in gonadotropin stimulated as compared to natural ovarian cycles. Exp Clin Endocrinol Diabetes 109: 345 - 349
Licht P, Russu V, Lehmeyer S, Wildt L (2001) Molecular aspects of direct LH/hCG effects on human endometrium – lessons from intrauterine microdialysis in the human female in vivo. Reprod Biol 1: 10-19
Licht P, Neuwinger J, Fischer O, Siebzehnrübl E, Wildt L (2002) VEGF plasma pattern in ovulation induction: evidence for an episodic secretion and lack of immediate effect of hCG. Exp Clin Endocrinol Diabetes 110: 130-133
Licht P, Russu V, Lehmeyer S, Möll J, Siebzehnrübl E, Wildt L (2002) Intrauterine microdialysis reveals a cycle-dependent regulation of endometrial insulin-like growth factor binding protein (IGFBP)-1 secretion by human chorionic gonadotropin in the human female in vivo. Fertil Steril 78: 252-258
Gebauer G, Fehm T, Beck EP, Berkholz A, Licht P, Jager W (2003) Cytotoxic effect of conjugates of doxorubicin and human chorionic goandotropin (hCG) in breast cancer cells. Brest Cancer Res Treat 77: 125-31
Licht P, v. Wolff M, Berkholz A, Wildt L (2003) Evidence for a cycle-dependent expression of full-length hCG/LH-receptor ribonucleic acid (mRNA) in human endometrium and decidua. Fertil Steril 79 (Suppl. 1): 718-23
Licht P, Russu V, Lehmeyer S, Wissentheit T, Siebzehnrübl E, Wildt L (2003) Cycle-dependency of intrauterine vascular endothelial growth factor levels are correlated to decidualisation and corpus luteum function. Fertil Steril 80: 1228-33
Moeller K-T, Schmidt A, Licht P, Hein A, Veitenhansel S, Wildt L (2003) Expiratorische CO2-Messung in der Zyklusüberwachung – ein einfacher und zuverlässiger Marker zur Bestimmung der fertilen Tage. J Fertil Reprod 13: 7-12
Licht P, Herberth J, Wallwiener D, Wildt L (2003) Evidence for a modulation of apoptosis by recombinant human choriogonadotropin (r-hCG) in uterine leiomyoma cell cultures. Geburtsh Frauenheilk 63: 1262-6
Gebauer G, Renner N, Fehm T, Berkholz A, Beck EP, Jaeger W, Licht P (2004) Expression and regulation of LH/hCG receptors in ovarian cancer and its correlation to doxorubicin sensitivity. Am J Obstet Gynecol 190: 1621-8
Filicori M, Rao CV, Huhtaniemi I, Licht P, Tesarik J, Zygmunt M (2005) Novel concepts of human chorionic gonadotropin: reproductive system interactions and potential in the management of infertility. Fertil Steril 84: 275-84
Fluhr H, Krenzer S, Deperschmidt M, Zwirner M, Wallwiener D, Licht P(2006) Human chorionic gonadotropin (hCG) inhibits IGFBP-1 and prolactin in decidualized human endometrial stromal cells. Fertil Steril 86: 236-8
Ott HW, Mattle V, Zimmermann U, Licht P, Moeller K, Wildt L (2006) Symptoms of the Premenstrual Syndrome may be caused by hyperventilation ? Fertil Steril 86: 1001-e17-19
Ott HW, Mattle V, Hadziomerovic D, Licht P, Doinghaus K, Rubbert A, Manger K, Manger B, Kalden J, Wildt L (2007) Treatment of hereditary angioneurotic oedema (HANE) with tibolone. Clin Endocrinol (Oxf) 66: 180-4
Sanches-Albisua I, Borell-Kost S, Mau-Holzmann UA, Licht P, Krägeloh-Mann I (2007) Increased frequency of severe major anomalies in children conceived by intracytoplasmatic sperm injection. Develop Med Child Neurol 49: 129-34
Licht P, Fluhr H, Neuwinger J, Wallwiener D, Wildt L (2007) Is human chorionic gonadotropin (hCG) directly involved in the regulation of human implantation. Mol Cell Endocrinol 269: 85-92
Fluhr H, Krenzer S, Stein G, Wesselborg S, Depperschmidt M, Wallwiener D, Zygmunt M, Licht P (2007) Interferon-gamma and tumor-necrosis-factor-alpha sensitize primarily resistant human endometrial stromal cells to FAS-mediated apoptosis. J Cell Sci 120: 4126-33
Fluhr H, Carli S, Depperschmidt M, Wallwiener D, Zygmunt M, Licht P (2008) Differential effects of human chorionic gonadotropin and decidualisation on insulin-like growth factors-I and -II in human endometrial cells. Fertil Steril 90(4 Suppl): 1384-9.
Fluhr H, Krenzer S, Depperschmidt M, Wallwiener D, Zygmunt M, Bishop P, Licht P (2008) Human chorionic gonadotropin stimulates matrix-metalloproteinase-2 and -9 in cytotrophoblastic dells and decreases tissue inhibitor of metalloproteinases -1, -2, and -3 in decidualized endometrial stromal cells. Fertil Steril 90(4 Suppl): 1390-5
Fluhr H, Ramp K, Krenzer S, Licht P, Zygmunt M (2009) Inverse regulation of the interferon-gamma receptor and its signaling in human endometrial stromal cells during decidualisation. Fertil Steril 91(5 Suppl): 2131-6.
Fluhr H, Sauter G, Steinmüller F, Licht P, Zygmunt M. (2009) Nonapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on interleukin-6, leukemia inhibitory factor, interleukin-8, and monocyte chemoattractant protein 1 vary between undifferentiated and decidualized human endometrial stromal cells. Fertil Steril 92: 1420-3
Fluhr H, Spratte J, Ehrhardt J, Steinmüller F, Licht P, Zygmunt M. (2010) Heparin and low-molecular-weight heparins modulate the decidualization of human endometrial stromal cells. Fertil Steril 15: 2581-7
Fortbildungs- und Opinionartikel
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Buchbeiträge
Licht P, Lei ZM, Rao ChV, Merz WE (1993) The presence and functional relevance of hCG/LH receptors in normal human placentae and choriocarcinomas. In: Barnea ER, Check JH, Grudzinskas JG, Maruo T (Edts.): Implantation and Early Pregnancy in Humans, S. 235-246, Parthenon Publishers.
Wildt L, Licht P, Neuwinger J (1995) Die Hyperandrogenämische Ovarialinsuffizienz: Neue therapeutische Ansatzpunkte aus endokrinologischer Sicht. In: Hensen J (Hrsg.): Fortschritte in Diagnostik und Therapie endokrinologischer Erkrankungen 1995, S. 175-193, W. Tümmels Verlag, ISBN 3-921590-30-2
Wildt L, Licht P, Roth B, Rabenbauer B (1997) Hirsutismus und Hypertrichose - Pathogenese, Diagnostik und Therapie. In: Peter HH, Pfreundschuh M, Philipp T, Schölmerich J, Schuster HP, Sybrecht GW (Hrsg.): Klinik der Gegenwart 1997, S. III, 4:1-32
Taubert HD, Licht P (2004) Normale Geschlechtsentwicklung und Entwicklungsstörungen. Gynäkologie und Geburtshilfe, 10. Auflage, Hrsg. Schmidt-Matthiesen,. Wallwiener, Schattauer Verlag
Taubert HD, Licht P (2004) Familienplanung. Gynäkologie und Geburtshilfe, 10. Auflage, Hrsg. Schmidt-Matthiesen,. Wallwiener, Schattauer Verlag
Taubert HD, Licht P (2004) Sterilität und Infertilität Gynäkologie und Geburtshilfe, 10. Auflage, Hrsg. Schmidt-Matthiesen, Wallwiener, Schattauer Verlag.
Licht P (2012) Diagnostik der Sterilität, Infertilität. Therapiehandbuch Gynäkologie und Geburtshilfe – evidence based. Hrsg. Wacker, Sillem, Springer Verlag, Heidelberg.